Preferential inhibition of lactate oxidation relative to glucose oxidation in the rat heart following diabetes
نویسندگان
چکیده
منابع مشابه
Preferential oxidation of glycogen in isolated working rat heart.
We tested the hypothesis that glycogen is preferentially oxidized in isolated working rat heart. This was accomplished by measuring the proportion of glycolytic flux (oxidation plus lactate production) specifically from glycogen which is metabolized to lactate, and comparing it to the same proportion determined concurrently from exogenous glucose during stimulation with epinephrine. After prela...
متن کاملDifferential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart.
Despite the fact that lactate and pyruvate are potential substrates for energy production in vivo, our understanding of the control and regulation of carbohydrate metabolism is based principally on studies where glucose is the only available carbohydrate. Therefore, the purpose of this study was to determine the contributions of lactate, pyruvate, and glucose to energy production in the isolate...
متن کاملPreferential oxidation of fatty acids by rat small intestine.
In a previous study from this laboratory it was shown that mitochondria can be harvested from rat small intestinal epithelial cells and that these mitochondria show intact oxidative phosphorylation [ 11. Further studies [2] showed that the isolated mitochondria are able to oxidize octanoate and palmitate completely to CO? and HzO, whereas earlier studies [3] showed that 3-hydroxybuty rate is al...
متن کاملLactate-stimulated ethanol oxidation in isolated rat hepatocytes.
1. Hepatocytes isolated from starved rats and incubated without other substrates oxidized ethanol at a rate of 0.8-0.9mumol/min per g wet wt. of cells. Addition of 10mm-lactate increased this rate 2-fold. 2. Quinolinate (5mm) or tryptophan (1mm) decreased the rate of gluconeogenesis with 10mm-lactate and 8mm-ethanol from 0.39 to 0.04-0.08mumol/min per g wet wt. of cells, but rates of ethanol ox...
متن کاملFatty Acid Oxidation and Stimulating Glucose Oxidation Malonyl Coenzyme A Decarboxylase Inhibition Protects the Ischemic Heart by Inhibiting
Abnormally high rates of fatty acid oxidation and low rates of glucose oxidation are important contributors to the severity of ischemic heart disease. Malonyl coenzyme A (CoA) regulates fatty acid oxidation by inhibiting mitochondrial uptake of fatty acids. Malonyl CoA decarboxylase (MCD) is involved in the decarboxylation of malonyl CoA to acetyl CoA. Therefore, inhibition of MCD may decrease ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 1999
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(99)00056-5